Arteriovenous Malformation of the Pancreas

Pancreatic arteriovenous malformation (PAVM) is a very rare and mostly congenital lesion, with less than 80 cases described in the English-published literature. It is defined as a tumorous vascular abnormality that is constructed between an anomalous bypass anastomosis of the arterial and venous networks within the pancreas. It represents about 5% of all arteriovenous malformations found in the gastrointestinal tract. Herein, we present a 64-year-old patient with symptomatic PAVM involving the body and tail of the organ, which was successfully treated by transcatheter arterial embolization. The disease spectrum and review of the literature are also presented

FWM-based wavelength conversion of 40 Gbaud PSK signals in a silicon germanium waveguide

We demonstrate four wave mixing (FWM) based wavelength conversion of 40 Gbaud differential phase shift keyed (DPSK) and quadrature phase shift keyed (QPSK) signals in a 2.5 cm long silicon germanium waveguide. For a 290 mW pump power, bit error ratio (BER) measurements show approximately a 2-dB power penalty in both cases of DPSK (measured at a BER of 10-9) and QPSK (at a BER of 10-3) signals that we examined

Investigating the entire course of telithromycin binding to Escherichia coli ribosomes

Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, binds to Escherichia coli ribosomes in a two-step process. During the first, rapidly equilibrated step, telithromycin binds to a low-affinity site (KT = 500 nM), in which the lactone ring is positioned at the upper portion of the peptide exit tunnel, while the alkyl–aryl side chain of the drug inserts a groove formed by nucleotides A789 and U790 of 23S rRNA. During the second step, telithromycin shifts slowly to a high-affinity site (KT* = 8.33 nM), in which the lactone ring remains essentially at the same position, while the side chain interacts with the base pair U2609:A752 and the extended loop of protein L22. Consistently, mutations perturbing either the base pair U2609:A752 or the L22-loop hinder shifting of telithromycin to the final position, without affecting the initial step of binding. In contrast, mutation Lys63Glu in protein L4 placed on the opposite side of the tunnel, exerts only a minor effect on telithromycin binding. Polyamines disfavor both sequential steps of binding. Our data correlate well with recent crystallographic data and rationalize the changes in the accessibility of ribosomes to telithromycin in response to ribosomal mutations and ionic changes

Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association?

A possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations. Herein, a case of a 39-year-old woman with FA tetraplegia, who was admitted in our department with intestinal obstruction due to a huge uterine tumor, is described. An abdominal CT revealed a huge intra-abdominal mass originating from the right cornu of the uterus. Tumor excision and adhesionlysis were performed. The histological examination of the tumor revealed a leiomyoma. FA patients seem to present with a variety of neoplasms uncommon for their young age. This is the first report of a leiomyoma originating from the genital system in a female patient with FA tetraplegia. Therefore it is important to identify neoplasms at an early stage in patients with FA and start immediate therapy

Flash Flood Susceptibility Evaluation in Human-Affected Areas Using Geomorphological Methods—The Case of 9 August 2020, Euboea, Greece. A GIS-Based Approach.

Flash floods occur almost exclusively in small basins, and they are common in small Mediterranean catchments. They pose one of the most common natural disasters, as well as one of the most devastating. Such was the case of the recent flood in Euboea island, in Greece, in August 2020. A field survey was accomplished after the 2020 flash floods in order to record the main impacts of the event and identify the geomorphological and man-made causes. The flash flood susceptibility in the urbanized alluvial fans was further assessed using a Geographic Information System (GIS)-based approach. Our findings suggest that a large portion of the alluvial fans of Politika, Poros and Mantania streams are mainly characterized by high and very high hazard. In fact, ~27% of the alluvial fans of Politika and Poros streams are characterized with very high susceptibility, and ~54% of Psachna area. GIS results have been confirmed by field observations after the 2020 flash flood, with significant damages noted, such as debris flows and infrastructure damages, in buildings, bridges and the road networks. In addition, even though the adopted approach may be more time-consuming in comparison to purely computational methods, it has the potential of being more accurate as it combines field observations and the effect of past flooding events

All-optical phase regeneration with record PSA extinction ratio in a low-birefringence silicon germanium waveguide

We report a low-power continuous wave-pumped phase sensitive amplifier (PSA)-based phase regenerator implemented in a passive silicon-based waveguide. A polarization assisted-PSA, consisting of two orthogonally-polarized pumps and a phase-locked signal copolarized to one of them, was implemented in a low-birefringence silicon germanium (SiGe) waveguide. The strong TE/TM modal symmetry of the waveguide and its large nonlinear coefficient enabled the achievement of an extremely large phase sensitive extinction ratio of approximately 29 dB for a total input power of only 21.3 dBm. This SiGe-based PSA was used to demonstrate phase regeneration on a 20 Gb/s differential phase-shift keying signal, thereby reducing its error vector magnitude and phase error by three and six times respectively and enabling a bit-error ratio improvement of up to 2 dB

ICT BONE views on the network of the future: the role of optical networking

Part of the activities of the ICT EU Network of Excellence “Building the future Optical Network in Europe” (BONE) project is the development of the European Roadmap on Optical Networking in the context of the “Network of the Future”. This paper presents a summary of the views of the BONE consortium as they were developed in the framework of the Roadmap activity. The methodology followed in the development of the BONE Roadmap was firstly to identify and analyse the status of broadband access penetration as well as the availability of specific network and IT technologies in various European countries. The data collected were then processed and translated into the traffic volume (distributed across different European countries) that a Pan- European network would need to support. This information is then used as the basis of a WDM optical network dimensioning exercise performed with the aim of identifying the scale of the required optical network. In addition, based on estimations regarding the evolution of broadband access technologies and the degree of broadband penetration and network services and applications, extrapolations regarding the growth of traffic to be supported by the European Network of the Future were made in a systematic manner. These were also used to dimension and understand the requirements of the European Network of the Future. This paper presents the relevant results and also provides a discussion on the BONE consortium views on the Network of the Future from an architectural and technology perspective and an outlook of the relevant key research challenges and possible solutions.Postprint (published version

Broadband telecom to mid-infrared supercontinuum generation in a dispersion-engineered silicon germanium waveguide

We demonstrate broadband supercontinuum generation (SCG) in a dispersion-engineered silicon-germanium waveguide. The 3 cm long waveguide is pumped by femtosecond pulses at 2.4 μm, and the generated supercontinuum extends from 1.45 to 2.79 μm (at the −30  dB point). The broadening is mainly driven by the generation of a dispersive wave in the 1.5–1.8 μm region and soliton fission. The SCG was modeled numerically, and excellent agreement with the experimental results was obtained